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Gardasil

GARDASIL®9 (Human Papillomavirus 9-valent Vaccine

Effectiveness of Gardasil in Prevention of HPV Types 6-, 11-, 16-, or 18-Related Genital Disease in Girls and Women 16 Through 26 Years of Age, Regardless of Current or Prior Exposure to Vaccine HPV TypesNot all vulvar, vaginal, and anal cancers are caused by HPV, and Gardasil protects only against those vulvar, vaginal, and anal cancers caused by HPV 16 and 18.

Merck and CSL Limited are expected[needs update] to market Gardasil as a cancer vaccine, rather than an STD vaccine. In the early years of Gardasil's introduction it was unclear how widespread the use of the three-shot series would be, in part because of its $525 list price ($175 each for three shots).[70] But as of 2013, vaccine coverage has been rising.[65] In 2013, about 55% of girls ages 13–17 years had at least one dose of the vaccination covered, up from 29% in 2007. Coverage for women ages 18–34 also has increased significantly since 2007.[65] The HPV vaccine protects against the two high-risk HPV types (types 16 and 18) which cause 70% of cervical cancers in women and 90% of all HPV-related cancers in men. It also protects against two low-risk HPV types (types 6 and 11), which cause 90% of genital warts The HPV virus (genital warts) in men can cause health problems. Genital warts are confined primarily to the moist skin of the genitals or around the anus. Genital warts are caused by the human papillomaviruses (HPVs), which are transmitted through sexual contact.Prophylactic efficacy against overall cervical and genital disease related to HPV 6, 11, 16, and 18 in an extension phase of Study 2, that included data through Month 60, was noted to be 100% (95% CI: 12.3%, 100.0%) among girls and women in the per protocol population naïve to the relevant HPV types.[L]et’s take a look at those 20,000 adverse events and 100 deaths and figure out what they mean. It’s absolutely clear that these are for the most part not side effects from Gardasil. Nor is the vaccine, which has been given to more than 10 million people, likely responsible for those deaths.

Dr. Diane Harper is one of the leading researchers in biomedical science, an individual who has spent her life studying vaccines. She has the academic training and research credibility at a level that if she said “Gardasil is dangerous,” many of us would stand up and begin to wonder. But the facts are she has not said anything of the sort about Gardasil and Cervarix. In peer-reviewed articles published in important, high impact journals, she has given strong, but scientifically qualified, endorsements to HPV vaccines. These are the facts. Any other allegations about her lack of support for vaccinations is based on misinformation, disinformation and lies.Anal HPV infection, AIN, and anal cancer were not endpoints in the studies conducted in women. The similarity of HPV-related anal disease in men and women supports bridging the indication of prevention of AIN and anal cancer to women.Disease prevention in women includes screening tests that are a basic part of prevention medicine. All screening tests are commonly available through your general doctor. Some specialized tests may be available elsewhere.

Gardasil was efficacious in reducing the incidence of CIN (any grade including CIN 2/3); AIS; genital warts; VIN (any grade); and VaIN (any grade) related to vaccine HPV types 6, 11, 16, or 18 in those who were PCR negative and seronegative at baseline (Table 11). The Cancer Institute NSW is Australia's first state-wide cancer control agency. We are dedicated to lessening the impact of cancer by keeping as many people off the cancer journey as possible, and improving outcomes in cancer diagnosis, treatment, care and ultimately, survival STN: 125126 Proper Name: Human Papillomavirus Quadrivalent (Types 6, 11, 16, 18) Vaccine, Recombinant Tradename: Gardasil Manufacturer: Merck & Co., Inc Indications: Prevention of vulvar and. Antibody levels at month 3 (one month post-dose number two) are substantially higher than at month 24 (18 months post-dose number three), suggesting that protection is achieved by month 3 and perhaps earlier.[23] In 2014, the World Health Organization (WHO) recommended that countries offer the vaccine in a two dose schedule to girls aged under 15, with each dose at least six months apart.[38][17] The United Kingdom, Switzerland, Mexico, and Quebec province of Canada are among the countries or territories that have implemented this as of June 2015[update]. The CDC recommended the vaccines be delivered in two shots over six months.[39]

Gardasil 9 (HPV Vaccine) Uses, Side Effects & Warnings

Some adults age 27 through 45 years who are not already vaccinated may decide to get HPV vaccine after speaking with their doctor about their risk for new HPV infections and the possible benefits of vaccination. HPV vaccination in this age range provides less benefit, as more people have already been exposed to HPV.Immunogenicity was measured by (1) the percentage of individuals who were seropositive for antibodies against the relevant vaccine HPV type, and (2) the Geometric Mean Titer (GMT).Naleway AL, Crane B, Smith N et al. Absence of venous thromboembolism risk following quadrivalent human papillomavirus vaccination, Vaccine Safety Datalink, 2008-2011external icon. Vaccine. 2016 Jan2; 34(1): 167-71. Epub 2015 Nov 6.The subject characteristics (e.g. lifetime sex partners, geographic distribution of the subjects) influence the HPV prevalence of the population and therefore the population benefit can vary widely.

Gardasil - Wikipedi

Gardasil is a human papillomavirus (HPV) vaccine. Gardasil is a sterile preparation for intramuscular injection and contains purified inactive proteins from HPV types 6, 11, 16, and 18. The proteins in Gardasil are structural, virus-like proteins (VLP) that resemble the HPV virus. The proteins can activate the immune system but cannot give rise to replicating virus. Viral proteins used in Gardasil are manufactured in yeast cells (S. cerevisiae) using recombinant technology. Once released from yeast cells, the VLPs are purified, combined with a catalyst (amorphous aluminum hydroxyphosphate sulfate) and a purification buffer. Human papillomavirus causes cervical cancer, cervical adenocarcinoma, vaginal cancer, genital warts, and anal cancer. Gardasil works by stimulating the immune system to attack HPV types 6, 11, 16, and 18. Once Gardasil is administered, the body's immune system recognizes the viral proteins in Gardasil as foreign, and develops antibodies against them, thus providing immunity from future infections. In the event of HPV exposure following vaccination, the body will already be primed to fight the infection. HPV types 6, 11, 16, and 18 are commonly associated with HPV infections. HPV 16 and 18 cause 70% of cervical cancer and HPV 6, 11, 16 and 18 cause approximately 90% of genital warts. The FDA approved Gardasil in June 2007.There was no increase in side effects when Gardasil was given at the same time as RECOMBIVAX HB [hepatitis B vaccine (recombinant)].Gardasil is a vaccine to prevent HPV, that, for maximum effect, is recommended for girls prior to their becoming sexually active.[citation needed] Moreover, evidence supports the conclusion that women who were already infected with one or more of the four HPV types targeted by the vaccine (HPV types 6, 11, 16, or 18) were protected from clinical disease caused by the remaining HPV types in the vaccine.[18] HPV types 16 and 18 cause an estimated 70% of cervical cancers,[13][14] and are responsible for most HPV-induced anal cancers.[15] Gardasil also protects against vulvar and vaginal cancers caused by HPV types 16 and 18,[16] as well as most penile cancers caused by these two HPV types.[29] Since Gardasil will not prevent infection with all of the HPV types that can cause cervical cancer, the vaccine is not considered a substitute for routine pap smears.[citation needed] Tell your health care provider if you have any of the following problems because these may be signs of an allergic reaction:

Long-term impact and cost-effectivenessedit

In clinical studies in 16- through 26-year-old girls and women, 99.8%, 99.8%, 99.8%, and 99.4% who received Gardasil became anti-HPV 6, anti-HPV 11, anti-HPV 16, and anti-HPV 18 seropositive, respectively, by 1 month postdose 3 across all age groups tested.Most children who get the first dose before 15 years of age need 2 doses of HPV vaccine. Anyone who gets the first dose on or after 15 years of age, and younger people with certain immunocompromising conditions, need 3 doses.  Your health care provider can give you more information.

Weinbaum CM, Cano M.  HPV vaccination and Complex Regional Pain Syndrome:  Lack of Evidence. external iconEbiomedicine. 2015 Aug 19; 2(9): 1014-5. eCollection 2015 Sep. Mention Gardasil, the Merck vaccine against four strains of the cancer-causing human papilloma virus, and you're likely to get a comment like this one, which reader Heather Meyers left on my.

GARDASIL® is First Cervical Cancer Vaccine to Receive WHO

Coronavirus COVID-19: Latest News and Information Sexually Transmitted Diseases (STDs) Slideshow Pictures Take the Quiz on STDs What is Gardasil Vaccine (HPV), and how does it work (mechanism of action)? What are the uses for Gardasil Vaccine (HPV)? What are the side effects of Gardasil Vaccine (HPV)? What is the dosage for Gardasil Vaccine (HPV)? Which drugs or supplements interact with Gardasil Vaccine (HPV)? Is Gardasil Vaccine (HPV) safe to take if I'm pregnant or breastfeeding? What else should I know about Gardasil Vaccine (HPV)? What is Gardasil Vaccine (HPV), and how does it work (mechanism of action)?HPV vaccine is routinely recommended for adolescents at 11 or 12 years of age to ensure they are protected before they are exposed to the virus.  HPV vaccine may be given beginning at age 9 years, and as late as age 45 years.

Urgent Warning About Gardasil - Snopes

"Vaccine Robbed My Daughter's Life" – 12 Year Old GirlWomen’s health in the spotlight at UNSW | UNSW Newsroom

Safety Information for Human Papillomavirus (HPV) Vaccine

Gardasil 9 FD

  1. Most people older than 26 years will not benefit from HPV vaccination. Talk with your health care provider if you want more information.
  2. How to use Gardasil Vial. Read all vaccine information available from your health care professional before receiving the vaccine.If you have any questions, ask your health care professional.. This.
  3. GARDASIL ® 9 (Human Papillomavirus 9-valent Vaccine, Recombinant) This private and confidential program provides vaccines free of charge to eligible individuals, primarily the uninsured who, without our assistance, could not afford needed Merck medicines

Gardasil (HPV Vaccine): Drug Facts, Side Effects and Dosin

Collected via e-mail, April 2009

An allergic reaction could occur after the vaccinated person leaves the clinic. If you see signs of a severe allergic reaction (hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness), call 9-1-1 and get the person to the nearest hospital. Patient Information about GARDASIL®9 (pronounced gard-Ah-sill nīn) (Human Papillomavirus 9-valent Vaccine,Recombinant) Read this information with care before getting GARDASIL®9. You or your child (the person getting GARDASIL9)will need 2 or3 doses of the vaccine, depending on how old you are. It is important torea

Gardasil - FDA prescribing information, side effects and use

  1. istration approved it for girls.
  2. Gardasil offers protection against cervical cancer, cervical dysplasias, vulvar or vaginal dysplasias and genital warts associated with HPV types 6, 11, 16 and 18. Cervarix offers protection against cervical cancer and cervical dysplasia associated with HPV types 16 and 18
  3. Human Papilloma Virus (HPV) Vaccine - Gardasil The Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention recommends HPV vaccine for girls and women 9-26 years of age to prevent cervical, vaginal and vulvar cancer as well as genital warts. In males, HPV has been associated with other types of cancers
  4. Among individuals who were positive (PCR positive and/or seropositive) for a vaccine HPV type at Day 1, endpoints related to that type were not included in the analyses of prophylactic efficacy. Endpoints related to the remaining types for which the individual was naïve (PCR negative and seronegative) were counted.
  5. Contact your health care provider right away if you get any symptoms that concern you, even several months after getting the vaccine.
  6. Gardasil is the brand name of the human papillomavirus (HPV) vaccine.. It's used to protect against cervical, anal, and vaginal cancers that are caused by HPV.. It's also used to prevent genital.
  7. Watch this slideshow on Viral Infections and learn about types, treatment, and prevention of illnesses caused by viruses.

Vaccine Information Statement HPV VIS CD

Sexually transmitted diseases (STDs) are infections transmitted during sexual contact. They may be caused by viruses, bacteria, or parasites. STDs in men cause no symptoms or symptoms like genital burning, itching, sores, rashes, or discharge. Common infections that are sexually transmitted in men include gonorrhea, chlamydia, syphilis, hepatitis C and B, genital warts, human papillomavirus (HPV), and genital herpes. Some STDs in men are treatable while others are not. STDs are diagnosed with tests that identify proteins or genetic material of the organisms causing the infection. The prognosis of an STD depends on whether the infection is treatable or not. Use of latex condoms can help reduce the risk of contracting an STD but it does not eliminate the risk entirely. Gardasil is a shot that is usually given in the arm muscle. You will need 3 shots given on the following schedule: Dose 1: at a date you and your health care provider choose. Dose 2: 2 months after Dose 1. Dose 3: 6 months after Dose 1. Fainting can happen after getting Gardasil. Sometimes people who faint can fall and hurt themselves Markowitz LE, Dunne EF, Saraiya M, Chesson HW, Curtis CR, Gee J, et al. Human papillomavirus vaccination: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2014; 63(RR05);1-30.The impact of Gardasil against the overall burden of dysplastic or papillomatous cervical, vulvar, and vaginal disease regardless of HPV detection, results from a combination of prophylactic efficacy against vaccine HPV types, disease contribution from vaccine HPV types present at time of vaccination, the disease contribution from HPV types not contained in the vaccine, and disease in which HPV was not detected.

Gardasil FD

  1. Human papillomavirus can cause genital warts, cancer of the cervix, anal cancer, and various cancers of the vulva or vagina.. HPV 9-valent vaccine is used in girls and young women ages 9 through 45 to prevent cervical/vaginal/anal cancers or genital warts caused by certain types of HPV.. HPV 9-valent vaccine is also used in boys and young men ages 9 through 45 to prevent anal cancer or genital.
  2. Gardasil and Cervarix are FDA-licensed HPV vaccines. The quadrivalent HPV recombinant vaccine (Gardasil) contains L proteins that reassemble to form an empty viral shell called a viral-like protein (VLP). Gardasil contains VLPs from serotypes 6, 11, 16, and 18. Cervarix is a bivalent vaccine that contains only serotypes 16 and 18. To sustain.
  3. ated encephalomyelitis, dizziness, Guillain-Barré syndrome, headache, motor neuron disease, paralysis, seizures, syncope (including syncope associated with tonic-clonic movements and other seizure-like activity) sometimes resulting in falling with injury, transverse myelitis.
  4. Conspiracy theorists misrepresent Bill Gates’ funding of vaccination and digital-identity research as evidence of a nefarious global surveillance plan foretold in the Book of Revelation.
  5. Gardasil does not protect against genital disease not related to HPV. One woman who received Gardasil in Study 3 developed an external genital well-differentiated squamous cell carcinoma at Month 24. No HPV DNA was detected in the lesion or in any other samples taken throughout the study.

Vaccine Information Statements (VISs) are information sheets produced by CDC that explain both the benefits and risks of a vaccine.Perry's decision was later criticized on September 12, 2011, by fellow presidential candidates Rick Santorum and Michele Bachmann during the Republican Party presidential debate as being an overreach of state power in a decision properly left to parents.[87] home/ women's health center/women's health a-z list/gardasil vaccine (hpv) article

Gardasil - Uses, Side Effects, Interactions - Canada

  1. In the clinical studies, 9- through 26-year-old boys and men were evaluated for new medical conditions that occurred over the course of follow-up. New medical conditions potentially indicative of a systemic autoimmune disorder seen in the group that received Gardasil or AAHS control or saline placebo are shown in Table 10. This population includes all boys and men who received at least one dose of Gardasil or AAHS control or saline placebo, and had safety data available.
  2. Gardasil is not indicated for women 27 years of age or older. However, safety data in women 16 through 45 years of age was collected, and 3819 women (Gardasil N = 1894 vs. AAHS control or saline placebo N = 1925) reported at least 1 pregnancy each.
  3. Research findings that pioneered the development of the vaccine began in 1991 by investigators Jian Zhou and Ian Frazer in The University of Queensland, Australia. Researchers at UQ found a way to form non-infectious virus-like particles (VLP), which could also strongly activate the immune system. Subsequently, the final form of the vaccine was developed in parallel, by researchers at Georgetown University Medical Center, the University of Rochester, the University of Queensland in Australia, and the U.S. National Cancer Institute.[77]
  4. istration. DESCRIPTION. GARDASIL, Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant, is a non-infectious recombinant quadrivalent vaccine prepared from the purified virus-like particles (VLPs) of the major capsid (L1) protein of HPV Types 6, 11, 16.
  5. CDC recommends that anyone starting the series before their 15th birthday receives two doses of HPV vaccine, with at least six months between the first and second dose. Adolescents who receive their two doses less than five months apart will require a third dose of HPV vaccine.Teens and young adults who start the series at ages 15 through 26 years still need three doses of HPV vaccine.  Also, three doses are recommended for people with certain immunocompromising conditions aged 9 through 26 years.
  6. A sub-study of Study 5 evaluated the efficacy of Gardasil against anal disease (anal intraepithelial neoplasia and anal cancer) in a population of 598 MSM. The primary analyses of efficacy were conducted in the per-protocol efficacy (PPE) population of Study 5.

Headache [0.02% Gardasil (3 cases) vs. 0.02% AAHS control (2 cases)], Gastroenteritis [0.02% Gardasil (3 cases) vs. 0.02% AAHS control (2 cases)], Appendicitis [0.03% Gardasil (5 cases) vs. 0.01% AAHS control (1 case)], Pelvic inflammatory disease [0.02% Gardasil (3 cases) vs. 0.03% AAHS control (4 cases)], Urinary tract infection [0.01% Gardasil (2 cases) vs. 0.02% AAHS control (2 cases)], Pneumonia [0.01% Gardasil (2 cases) vs. 0.02% AAHS control (2 cases)], Pyelonephritis [0.01% Gardasil (2 cases) vs. 0.02% AAHS control (3 cases)], Pulmonary embolism [0.01% Gardasil (2 cases) vs. 0.02% AAHS control (2 cases)].Naleway AL, Mittendorf KF, Irving, SA, Henninger ML, Crane B, Smith N, Daley MF, Gee J. Primary Ovarian Insufficiency and Adolescent Vaccination. external icon Pediatrics. 2018 Sep; 142(3). Epub 2018 Aug 21. Gardasil is a new entrant to the market, having been approved by the Food and Drug Administration in June. The vaccine has been approved for girls as young as nine years old, to protect them later. The vaccine was approved for medical use in the United States in 2006,[19][20] initially for use in females aged 9–26.[21] In 2007, the Advisory Committee on Immunization Practices (ACIP) recommended gardasil for routine vaccination of girls aged 11 and 12 years.[22] As of August 2009, vaccination was recommended before adolescence and the beginning of potential sexual activity.[11][23][24] By 2011, the vaccine had been approved in 120 other countries.[25] Gardasil, trade name of human papillomavirus (HPV) quadrivalent (types 6, 11, 16, and 18) vaccine, recombinant, the first HPV vaccine used primarily to prevent cervical cancer in women. It was developed by Scottish-born Australian immunologist Ian Frazer. Learn more about Gardasil's use and history

How you can get GARDASIL ® 9 The GARDASIL ® 9 vaccine is available for purchase at many health clinics and most pharmacies. GARDASIL ® 9 is offered to elementary school boys & girls - and certain adults - through publicly-funded programs across Canada. Visit our provincial programs page to learn more Headache was the most commonly reported systemic adverse reaction in both treatment groups (Gardasil = 12.3% and AAHS control or saline placebo = 11.2%). Fever was the next most commonly reported systemic adverse reaction in both treatment groups (Gardasil = 8.3% and AAHS control or saline placebo = 6.5%).Gardasil should be administered intramuscularly as a 0.5-mL dose at the following schedule: 0, 2 months, 6 months. [See Clinical Studies (14.8).]Gardasil should be administered intramuscularly in the deltoid region of the upper arm or in the higher anterolateral area of the thigh.

HPV vaccine: Who needs it, how it works - Mayo Clini

An alternative vaccine known as Cervarix protects against two oncogenic strains of HPV, 16 and 18.[35] Men who have sex with men (MSM) are particularly at risk for conditions associated with HPV types 6, 11, 16, and 18; diseases and cancers that have a higher incidence among MSM include anal intraepithelial neoplasias, anal cancers, and genital warts. Type 16 is also associated with oropharyngeal squamous-cell carcinoma, a form of throat cancer.[48] A 2005 study found that 95% of HIV-infected gay men also had anal HPV infection, of whom 50% had precancerous HPV-caused lesions.[49]

HPV Vaccine for Children: Gardasil and Cervarix Pros and

GARDASIL is approved for use in more than 125 countries. To date, more than 111 million doses have been distributed worldwide; however, it is not known how many doses have been administered The following adverse events have been spontaneously reported during post-approval use of Gardasil. Because these events were reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or to establish a causal relationship to vaccine exposure.

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Headache was the most commonly reported systemic adverse reaction in both treatment groups (Gardasil = 28.2% and AAHS control or saline placebo = 28.4%). Fever was the next most commonly reported systemic adverse reaction in both treatment groups (Gardasil = 13.0% and AAHS control or saline placebo = 11.2%).In 7 clinical trials (5 Amorphous Aluminum Hydroxyphosphate Sulfate [AAHS]-controlled, 1 saline placebo-controlled, and 1 uncontrolled), 18,083 individuals were administered Gardasil or AAHS control or saline placebo on the day of enrollment, and approximately 2 and 6 months thereafter, and safety was evaluated using vaccination report cards (VRC)-aided surveillance for 14 days after each injection of Gardasil or AAHS control or saline placebo in these individuals. The individuals who were monitored using VRC-aided surveillance included 10,088 individuals 9 through 45 years of age at enrollment who received Gardasil and 7,995 individuals who received AAHS control or saline placebo. Few individuals (0.2%) discontinued due to adverse reactions. The race distribution of the 9- through 26-year-old girls and women in the safety population was as follows: 62.3% White; 17.6% Hispanic (Black and White); 6.8% Asian; 6.7% Other; 6.4% Black; and 0.3% American Indian. The race distribution of the 24- through 45-year-old women in the safety population of Study 6 was as follows: 20.6% White; 43.2% Hispanic (Black and White); 0.2% Other; 4.8% Black; 31.2% Asian; and 0.1% American Indian. The race distribution of the 9- through 26-year-old boys and men in the safety population was as follows: 42.0% White; 19.7% Hispanic (Black and White); 11.0% Asian; 11.2% Other; 15.9% Black; and 0.1% American Indian.

Viagra Connect | LloydsPharmacy Online Doctor UK

Gardasil (PF) Intramuscular : Uses, Side Effects

Specific Catch-up Recommendations for Gardasil 9® Vaccine Doses of Gardasil 9® recommended if adolescent currently aged ≤14 years (i.e. < 15 years) No. of Gardasil (HPV) doses given previously Doses of Gardasil 9® (HPV9) recommended No previous doses Two doses needed, give at least 6 months apart Give at 0, 6-12 month Women who receive Gardasil during pregnancy are encouraged to contact Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., at 1-877-888-4231 or VAERS at 1-800-822-7967 or www.vaers.hhs.gov.The safety of Gardasil when administered concomitantly with Menactra [Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine] and Adacel [Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (Tdap)] was evaluated in a randomized study of 1040 boys and girls with a mean age of 12.6 years [see Clinical Studies (14.11)]. The race distribution of the study subjects was as follows: 77.7% White; 1.4% Multi-racial; 12.3% Black; 6.8% Hispanic (Black and White); 1.2% Asian; 0.4% American Indian, and 0.2% Indian. Severe allergic reactions following vaccination are rare, but can be life threatening. Symptoms of a severe allergic reaction may include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. VACCINE INFORMATION STATEMENT HPV Vaccine. What You Need to Know. 1. What is HPV? Genital . human papillomavirus (HPV) is the most common sexually transmitted virus in the United States. More than half of sexually active men and women are infected with HPV at some time in their Gardasil ® 5 What are the.

GARDASIL 9 is indicated in boys and men 9 through 45 years of age for the prevention of the following diseases: Anal cancer caused by HPV types 16, 18, 31, 33, 45, 52, and 58. (1.2) Genital warts. Shake well before use. Thorough agitation immediately before administration is necessary to maintain suspension of the vaccine. Gardasil should not be diluted or mixed with other vaccines. After thorough agitation, Gardasil is a white, cloudy liquid. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Do not use the product if particulates are present or if it appears discolored.

Gardasil is a vaccine. It is a suspension for injection that contains purified proteins for four types of the human papillomavirus (types 6, 11, 16 and 18). It is available in vials or prefilled syringes. What is Gardasil used for? Gardasil is used in males and females from the age of nine years to protect against the following conditions. The .gov means it’s official.Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.HPV is spread through intimate skin-to-skin or sexual contact.  HPV infections are so common that nearly all men and women will get at least one type of HPV at some time in their lives. Human Papilloma Virus (Gardasil 9) $235.79 The human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. HPV can cause cervical cancer in women Gee J, Naleway A, Shui I et al. Monitoring the safety of quadrivalent human papillomavirus vaccine: findings from the Vaccine Safety Datalinkexternal icon. Vaccine. 2011 Oct 26; 29(46): 8279-84. Epub 2011 Sep 9.

Overall, 55 and 65 women in the group that received Gardasil or AAHS control or saline placebo, respectively (2.9% and 3.4% of all women who reported a pregnancy in the respective vaccination groups), experienced a serious adverse reaction during pregnancy. The most common events reported were conditions that can result in Caesarean section (e.g., failure of labor, malpresentation, cephalopelvic disproportion), premature onset of labor (e.g., threatened abortions, premature rupture of membranes), and pregnancy-related medical problems (e.g., pre-eclampsia, hyperemesis). The proportions of pregnant women who experienced such events were comparable between the groups receiving Gardasil and AAHS control or saline placebo.Landazabal CS, Moro PL, Lewis P, Omer SB. Safety of 9-valent human papillomavirus vaccine administration among pregnant women: Adverse event reports in the Vaccine Adverse Event Reporting System (VAERS), 2014-2017external icon. Vaccine. 2019 Feb 21; 37(9): 1229-1234. Epub 2019 Jan 16.

Side Effects of Gardasil (Quadrivalent Human

Shots,needles,and vaccines oh my! - YouTubeNatural Vitamin E May Help Prevent Lung Cancer

The study's authors argued that complaints of autoimmune disorders tied to Gardasil and Cervarix (which were approved for use by the U.S. Food and Drug Administration in 2006 and 2007 and have. The clinical trials included girls and women regardless of current or prior exposure to vaccine HPV types, and additional analyses were conducted to evaluate the impact of Gardasil with respect to HPV 6-, 11-, 16-, and 18-related cervical and genital disease in these girls and women. Here, analyses included events arising among girls and women regardless of baseline PCR status and serostatus, including HPV infections that were present at the start of vaccination as well as events that arose from infections that were acquired after the start of vaccination.Immune system disorders: Autoimmune diseases, hypersensitivity reactions including anaphylactic/anaphylactoid reactions, bronchospasm, and urticaria.Most HPV infections go away by themselves within 2 years. But sometimes HPV infections will last longer and can cause cancers later in life.In June 2013, the Japanese government issued a notice that "cervical cancer vaccinations should no longer be recommended for girls aged 12 to 16" while an investigation is conducted into certain adverse events including pain and numbness in 38 girls.[88] The vaccines sold in Japan are Cervarix, made by GlaxoSmithKline of the United Kingdom, and Gardasil, made by Merck Sharp & Dohme. An estimated 3.28 million people have received the vaccination; 1,968 cases of possible side effects have been reported.[89] In January 2014, the Vaccine Adverse Reactions Review Committee concluded that there was no evidence to suggest a causal association between the HPV vaccine and the reported adverse events, but did not reinstate proactive recommendations for its use.[90] A study on girls in Sapporo showed that since the Japanese government's suspension of recommending the vaccine, completion rates for the full course of vaccination have dropped to 0.6%.[90]

Since penile and anal cancers are much less common than cervical cancer, HPV vaccination of young men is likely to be much less cost-effective than for young women yet is still recommended due to the existent risk (including oral cancer).[55] Centers for Disease Control.   “Reports of Health Concerns Following HPV Vaccination.”     3 March 2009.When you are pregnant, many sexually transmitted diseases (STDs) can be especially harmful to you and your baby. These STDs include herpes, HIV/AIDS, genital warts (HPV), hepatitis B, chlamydia, syphilis, gonorrhea, and trichomoniasis. Symptoms include bumps, sores, warts, swelling, itching, or redness in the genital region. Treatment of STDs while pregnant depends on how far along you are in the pregnancy and the progression of the infection.Appropriate medical treatment and supervision must be readily available in case of anaphylactic reactions following the administration of Gardasil.

A total of 27% of 16- through 26-year-old girls and women, 33% of 24- through 45-year-old women, and 17% of 16- through 26-year-old boys and men had evidence of prior exposure to or ongoing infection with at least 1 of the 4 vaccine HPV types. Among these individuals, 74% of 16- through 26-year-old girls and women, 71% of 24- through 45-year-old women, and 78% of 16- through 26-year-old boys and men had evidence of prior exposure to or ongoing infection with only 1 of the 4 vaccine HPV types and were naïve (PCR negative and seronegative) to the remaining 3 types.People with minor illnesses, such as a cold, may be vaccinated. People who are moderately or severely ill should usually wait until they recover before getting HPV vaccine.HPV only infects human beings. Animal studies with analogous animal papillomaviruses suggest that the efficacy of L1 VLP vaccines may involve the development of humoral immune responses. Human beings develop a humoral immune response to the vaccine, although the exact mechanism of protection is unknown.

The CDC, in conjunction with the Food and Drug Administration (FDA), operates a program known as the Vaccine Adverse Event Reporting System (VAERS). The VAERS program collects and analyzes reports on adverse events following immunizations in order to help track the safety and efficacy of various vaccines. It is important to note that reports collected by VAERS are raw data; they do not in themselves establish causal connections between vaccines and adverse medical issues — such determinations cannot be made until the reports have been investigated, evaluated, and analyzed.In clinical studies in boys and men aged 16 through 26 years, efficacy was evaluated using the following endpoints: external genital warts and penile/perineal/perianal intraepithelial neoplasia (PIN) grades 1/2/3 or penile/perineal/perianal cancer. In addition, cases of AIN grades 1/2/3 and anal cancer made up the composite efficacy endpoint used to assess prevention of HPV-related anal cancer.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. The CDC recommends the Gardasil vaccine, made by Merck Pharmaceuticals, for all females between 9 and 26 years to protect against HPV.Furthermore, the CDC says Gardasil is licensed, safe, and.

Gardasil (Human Papillomavirus Vaccine) - Side Effects

Safety in Concomitant Use with RECOMBIVAX HB® [hepatitis B vaccine (recombinant)] in Girls and Women 16 Through 23 Years of AgeSubscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more. Gardasil 9 is a vaccine that's used to prevent certain diseases caused by human papillomavirus (HPV).. HPV is a virus that can cause very serious conditions such as cervical, vulvar, vaginal.

In December 2014, the FDA approved Gardasil-9, which protects against nine strains of HPV.[78] The Dangers of Gardasil (HPV/Cervical Cancer Vaccine) February 15 · ‍♀️ ‍♂️ This flawed vaccine was a celebrated moneymaker after Merck's VIOXX drama Results from clinical studies indicate that Gardasil may be administered concomitantly (at a separate injection site) with Menactra [Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine] and Adacel [Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (Tdap)] [see Clinical Studies (14.11)].While an Italian politician truly did call for Bill Gates to be arrested, this position has not been endorsed by the Italian government.

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Moro PL, Zheteyeva Y, Lewis P, Shi J, Yue X, Museru OI, et al. Safety of quadrivalent human papillomavirus vaccine (Gardasil®) in pregnancy: Adverse events among non-manufacturer reports in the Vaccine Adverse Event Reporting System, 2006-2013external icon. Vaccine. 2015 Jan 15; 33(4): 519-22. Epub 2014 Dec 8. GARDASIL 9 is a vaccine indicated in females 9 through 45 years of age for the prevention of cervical, vulvar, vaginal, and anal cancers caused by human papillomavirus (HPV) Types 16, 18, 31, 33, 45, 52, and 58; precancerous or dysplastic lesions caused by HPV Types 6, 11, 16, 18, 31, 33, 45, 52, and 58; and genital warts caused by HPV Types 6 and 11 Gardasil administered to female rats at a dose of 120 mcg total protein, which is equivalent to the recommended human dose, had no effects on mating performance, fertility, or embryonic/fetal survival.Read this information with care before getting Gardasil1. You (the person getting Gardasil) will need 3 doses of the vaccine. It is important to read this leaflet when you get each dose. This leaflet does not take the place of talking with your health care provider about Gardasil.

Three doses of the human papillomavirus (HPV) vaccine are needed in order for the vaccine to be effective, health officials say, but many people who start the vaccination series don't finish it INFORMATION ABOUT GARDASIL. GARDASIL is a human papillomavirus (HPV) vaccine that helps protect against 4 types of HPV. In girls and young women ages 9 to 26, GARDASIL helps protect against 2 types of HPV that cause 70% of cervical cancer cases, 70% of vaginal cancer cases, and up to 50% of vulvar cancer cases Gardasil ® (HPV4 vaccine) has been authorized for use in Canada since 2006 for the prevention of infection caused by HPV types 6, 11, 16 and 18 -related cancers and genital warts. Cervarix ™ (HPV2 vaccine) has been authorized for use in Canada since 2010 for the prevention of cervical cancer caused by HPV types 16 and 18 Hanson KE, McLean HQ, Belongia, EA, Stokley S, McNeil MM, Gee J, VanWormer JJ. Sociodemographic and clinical correlates of human papillomavirus vaccine attitudes and receipt among Wisconsin adolescentsexternal icon. Papillomavirus. Res. 2019 May 25; 8: 1001568. Epub ahead of print.

Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People Search Search Icon Close Icon × Vaccines site Vaccines site All CDC Submit For a full list of topics: All A-Z Topics Advanced Search Advanced Search Vaccine Information Statements (VISs) Section Navigation CDC Home Facebook Twitter LinkedIn Email Syndicate HPV (Human Papillomavirus) VIS Minus Related Pages Current Edition Date: 10/30/2019 Human papillomavirus (HPV) is a virus almost everyone will be infected with at some point in their lives. HPV is spread through intimate contact even when an infected person has no signs or symptoms. In most cases, HPV goes away on its own and people infected with the virus never knew they had it Gardasil 9 (human papillomavirus (HPV)) vaccine is used in both females and males.Human papillomavirus (HPV) can cause genital warts, cancer of the cervix, anal cancer, and various cancers of the vulva or vagina. Gardasil 9 vaccine is used in girls and women ages 9 through 45 to prevent cervical/vaginal/anal cancers or genital warts caused by certain types of HPV HPV and HPV Testing. What are viruses? Viruses are very small organisms - most cannot even be seen with a regular microscope. They cannot reproduce on their own. They must enter a living cell, which becomes the host cell, and hijack the cell's machinery to make more viruses An analysis of injection-site adverse reactions in girls and women by dose is shown in Table 3. Of those girls and women who reported an injection-site reaction, 94.3% judged their injection-site adverse reaction to be mild or moderate in intensity.

The protection of Gardasil against HPV-related disease continues to be studied over time in populations including adolescents (boys and girls) and women who were enrolled in the Phase 3 studies. The HPV vaccine, also know by the brand name Gardasil, first became available in 2006. READ MORE Hoda Kotb has 'loved every second' of maternity leave, announces return to 'Today The oncogenic viral types (HPV 16 and 18) and wart-causing viral types (HPV 6 and 11) are the targets for the quadrivalent vaccine (Gardasil ®, Merck & Company, Whitehouse Station, New Jersey, USA). A bivalent vaccine for HPV 16 and 18 has been marketed for female vaccine programs (Cervarix ® , GSK, Research Triangle Park, North Carolina, USA. Copyright © 2006, 2009, 2010, 2011 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. All rights reserved.

Hojas de información sobre vacunas están disponibles en español y en muchos otros idiomas. Visite http://www.immunize.org/vis/vis_spanish.aspexternal icon The future expectations women hold because they have received free doses of Gardasil purchased by philanthropic foundations, by public health agencies or covered by insurance is the true threat.

Child and Adult Immunization Schedules Get CDC’s official recommended immunization schedules for children, adolescents, and adults.Gardasil 0.5 ml is injected intramuscularly as three separate doses. The first dose is administered at the patient's convenience, the second dose two months after the first dose, and the third dose six months after the first dose.Girls and women evaluated in the PPE population of clinical studies received all 3 vaccinations within 1 year of enrollment. An analysis of immune response data suggests that flexibility of ±1 month for Dose 2 (i.e., Month 1 to Month 3 in the vaccination regimen) and flexibility of ±2 months for Dose 3 (i.e., Month 4 to Month 8 in the vaccination regimen) do not impact the immune responses to Gardasil.

The overall efficacy of Gardasil will vary with the baseline prevalence of HPV infection and disease, the incidence of infections against which Gardasil has shown protection, and those infections against which Gardasil has not been shown to protect.The impact of Gardasil against the overall burden of dysplastic or papillomatous anogenital disease regardless of HPV detection, results from a combination of prophylactic efficacy against vaccine HPV types, disease contribution from vaccine HPV types present at time of vaccination, the disease contribution from HPV types not contained in the vaccine, and disease in which HPV was not detected.Vaccine is prepared from fermentation cultures of a recombinant strain of yeast Saccharomyces cerevisiae containing the genes for the human papillomavirus L1 protein of each type (6, 11, 16, 18). Contains no preservative or antibiotics.In clinical studies, women underwent urine pregnancy testing prior to administration of each dose of Gardasil. Women who were found to be pregnant before completion of a 3-dose regimen of Gardasil were instructed to defer completion of their vaccination regimen until resolution of the pregnancy.The safety and effectiveness of Gardasil have not been evaluated in a geriatric population, defined as individuals aged 65 years and over.

One case (0.006% Gardasil; 0.0% AAHS control or saline placebo) of bronchospasm; and 2 cases (0.01% Gardasil; 0.0% AAHS control or saline placebo) of asthma were reported as serious systemic adverse reactions that occurred following any vaccination visit.The duration of immunity following a complete schedule of immunization with Gardasil has not been established. The peak anti-HPV GMTs for HPV types 6, 11, 16, and 18 occurred at Month 7. Anti-HPV GMTs for HPV types 6, 11, 16, and 18 were similar between measurements at Month 24 and Month 60 in Study 2.Vaginal cancer is fairly uncommon. There are two types of vaginal cancer: squamous cell carcinoma and adenocarcinoma. Risk factors include being 60 or older, exposure to DES while in the womb, HPV infection, and having a history of abnormal cervical cells. Painful intercourse, pelvic pain, vaginal lumps, and abnormal vaginal bleeding or discharge are all symptoms of vaginal cancer. Treatment depends upon the stage of the vaginal cancer and may involve surgery, radiation therapy, chemotherapy, and the use of radiosensitizers.The message quoted above warns that the Centers for Disease Control (CDC) has already received nearly 12,000 complaints about adverse medical issues related to Gardasil vaccinations, and that 32 young women died after receiving Gardasil vaccinations. Although this information is accurate in a strictly literal sense, it is a misleading presentation of raw data that does not in itself establish a causal connection between Gardasil and the posited medical dangers.

Two of these vaccines (Gardasil and Gardasil 9) also protect against most genital warts. Both vaccines are recommended for 11 and 12 year-old girls, and for females 13 through 26 years of age, who did not get any or all of the shots when they were younger In addition, protection against HPV types 6 and 11 may eliminate up to 90% of the cases of genital warts.[17] Common plantar warts—e.g., caused by HPV types 1, 2, and 4[30]—are not prevented by this vaccine. Children's health is focused on the well-being of children from conception through adolescence. There are many aspects of children's health, including growth and development, illnesses, injuries, behavior, mental illness, family health, and community health.VanWormer JJ, Bendixsen CG, Vickers ER et al. Association between parent attitudes and receipt of human papillomavirus vaccine in adolescentsexternal icon. BMC Public Health. 2017 Oct 2; 17(1): 766.

As with any medicine, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death.Gardasil is given in three injections over six months. The second injection is two months after the first, and the third injection is six months after the first shot was administered.[11][23] Alternatively, in some countries it is given as two injections with at least six months between them, for individuals aged 9 years up to and including 13 years.[2][50] Adolescents aged 9-18 years are recommended to receive 9vHPV vaccine. The optimal age for HPV vaccination is around 12-13 years. The recommended schedule for adolescents aged 9-14 years is 2 doses, with a 6-12-month interval between doses. 1-5 The recommended schedule for adolescents aged 15-18 years (that is, past their 15th birthday) at the time of their 1st HPV vaccine is 3 doses. (To illustrate this concept, we offer the following [admittedly far-fetched] scenario: A man who received a flu vaccination and then accidentally hit his hand with a hammer a few hours later might legitimately report that soon after he received the flu vaccine, his hand began to throb painfully. Although such a report would be literally true, it would not establish any causal connection between the flu vaccine and the adverse medical symptom of a throbbing, painful hand.)

Gardasil has not been demonstrated to protect against diseases due to HPV types not contained in the vaccine. [See Clinical Studies (14.4, 14.5).]In 18,150 girls and women enrolled in Study 2, Study 3, and Study 4, Gardasil reduced definitive cervical therapy procedures by 23.9% (95% CI: 15.2%, 31.7%).

Concomitant administration of Gardasil with RECOMBIVAX HB [hepatitis B vaccine (recombinant)] did not interfere with the antibody response to any of the vaccine antigens when Gardasil was given concomitantly with RECOMBIVAX HB or separately. The quadrivalent HPV-6/11/16/18 L1 virus-like-particle vaccine with amorphous aluminum hydroxyphosphate sulfate (Gardasil, Merck) as an adjuvant and the aluminum-containing placebo were visually. Gee J, Naleway A, Shui I, Baggs J, Yinc R, Lic R, et al. Monitoring the safety of quadrivalent human papillomavirus vaccine: Findings from the Vaccine Safety Datalinkexternal icon, Vaccine. 2011; 29 (46) 8279-8284.

The primary analyses of efficacy with respect to HPV types 6, 11, 16, and 18 were conducted in the per-protocol efficacy (PPE) population, consisting of girls and women who received all 3 vaccinations within 1 year of enrollment, did not have major deviations from the study protocol, and were naïve (PCR negative in cervicovaginal specimens and seronegative) to the relevant HPV type(s) (Types 6, 11, 16, and 18) prior to dose 1 and through 1 month Postdose 3 (Month 7). Efficacy was measured starting after the Month 7 visit.Women's health is an important topic area to guide a woman through the stages of her life, as well as knowing the conditions and diseases that may occur. Educating yourself so that the transitions into different phases of life is key to a healthy, happy, and productive life. After the Toronto Star published a series of tragic stories detailing medical complications young women faced after receiving the Gardasil vaccine, Ottawa-based medical expert Dr. Yoni Freedhoff. Contact your healthcare provider. Important: If you are experiencing a medical emergency, seek immediate assistance from a healthcare provider or call 9-1-1. CDC and FDA do not provide individual medical treatment, advice, or diagnosis. If you need individual medical or health care advice, consult a qualified healthcare provider Stokley S, Jeyarajah J, Yankey D, Cano M, Gee J, Roark J, Curtis RC, Markowitz L.  Human papillomavirus vaccination coverage among adolescents, 2007-2013, and postlicensure vaccine safety monitoring, 2006-2014—United States.external icon MMWR Morb Mortal Wkly Rep. 2014 Jul 25; 63(29): 620-4.

The immunogenicity of Gardasil was assessed in 23,951 9- through 45-year-old girls and women (Gardasil N = 12,634; AAHS control or saline placebo N = 11,317) and 5417 9- through 26-year-old boys and men (Gardasil N = 3109; AAHS control or saline placebo N = 2308). Housing & Residence Life. Physical Address: 1080 West 6th St. Moscow, Idaho 83844. Mailing Address: Business Mail: 875 Perimeter Drive MS 2010 Moscow, ID 83844-201 In 2014, the FDA approved a nine-valent version, Gardasil 9, to protect against infection with the strains covered by the first generation of Gardasil as well as five other HPV strains responsible for 20% of cervical cancers (types 31, 33, 45, 52, and 58).[3][26][27] In 2018, the FDA approved expanded use of Gardasil 9 for individuals 27 through 45 years old.[28] Gardasil, suspension for injection in a pre-filled syringe: • Gardasil may appear as a clear liquid with a white precipitate prior to agitation. • Shake well before use, the pre-filled syringe, to make a suspension. After thorough agitation, it is a white, cloudy liquid As the CDC stated in its 2009 article on “Reports of Health Concerns Following HPV Vaccination,” before the Gardasil HPV vaccine was licensed it was studied in five clinical trials involving over 21,000 girls and women of ages 9 through 26. Since that licensing the “CDC and FDA have been closely monitoring the safety of the HPV vaccine” and found that:

Gardasil® is a vaccine indicated in girls and women 9 through 26 years of age for the prevention of the following diseases caused by Human Papillomavirus (HPV) types included in the vaccine:Fainting can happen after getting Gardasil. Sometimes people who faint can fall and hurt themselves. For this reason, your health care provider may ask you to sit or lie down for 15 minutes after you get Gardasil. Some people who faint might shake or become stiff. This may require evaluation or treatment by your health care provider. GARDASIL 9 is a vaccine indicated in girls and women 9 through 45 years of age for the prevention of the following diseases: Cervical, vulvar, vaginal, and anal cancer caused by Human Papillomavirus (HPV) types 16, 18, 31, 33, 45, 52, and 58.1. Gardasil, technically known as recombinant human papillomavirus vaccine [types 6, 11, 16, 18],[3][4][5][6][7] is a vaccine for use in the prevention of certain strains of human papillomavirus (HPV).[8] High-risk human papilloma virus (hr-HPV) genital infection is the most common sexually transmitted infection among women.[9] The HPV strains that Gardasil protects against are sexually transmitted,[10] specifically HPV types 6, 11, 16 and 18.[11][12] HPV types 16 and 18 cause an estimated 70% of cervical cancers,[13][14] and are responsible for most HPV-induced anal,[15] vulvar, vaginal,[16] and penile cancer cases.[15] HPV types 6 and 11 cause an estimated 90% of genital warts cases.[17] Though Gardasil does not treat existing infection, vaccination is still recommended for HPV-positive individuals, as it may protect against one or more different strains of the disease.[18] Gardasil is a vaccine used in girls and women 9 through 26 years of age for the prevention of the following diseases caused by Human Papillomavirus (HPV):

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